Ria Damayanti, Machlusil Husna, Yeni Quinta Mondiani, Shahdevi Nandar Kurniawan
  MNJ, pp. 77-81  


Background: Epilepsy is a major chronic neurological problem in the world. The goal of epilepsy therapy is seizure-free and without side effects. The emergence of side effects in patients with epilepsy will be its limitations that can cause the failure of epilepsy therapy. Therefore, it is necessary to do a simple descriptive study, which illustrates the pattern of side effects of anti-epileptic drugs that occur in people with epilepsy, so that later clinicians are more alert and can take preventative measures.

Objective: Knowing the pattern of side effects of antiepileptic drugs at the Neurology Outpatient Clinic dr. Saiful Anwar hospital.

Methods: This research is an observational descriptive study. Samples were taken by filling the questionnaire at the Neurology Outpatient Clinic dr. Saiful Anwar hospital. Demographic data in this study will be presented in the frequency distribution table. Chi Square test is used to determine the relationship of demographic data, also the pattern of therapy with the side effects that arise.

Results: 93 epilepsy patients were involved in the study. More than 40% of patients experience side effects. The most common side effects appear in idiopathic epilepsy (30.1%). Based on the duration of epilepsy, the most side effects appear in epilepsy duration> 10 years (17.2%). However, from the results of the influence test using chi square, there was no significant difference between the duration of epilepsy with the appearance of side effects, even the type of epilepsy (p-value> 0.05). 28 patients who experience side effects, appear after the duration of use of AED 1 - 5 years. It was found that the duration of AED uses affected the emergence of side effects (p-value <0.05).

Conclusion: Side effects occur in patients taking anti-epileptic drugs, and are related to the duration of drug use. This data can be used to increase the awareness of clinicians related to the emergence of side effects in patients who consume AED.


Epilepsy, antiepileptic drugs, side effects

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Kusumastuti, K., Gunadharma, S. and Kustiowati, E. Pedoman Tatalaksana Epilepsi, Pusat Penerbitan dan Percetakan Unair. 2017.

Joshi R, Tripathi M, Gupta P, Gulati. Adverse effects and drug load of antiepileptic drugs in patients with

epilepsy: Monotherapy versus polytherapy. Indian J Med Res; 2017. 145:317-326.

DOI: 10.4103/ijmr.IJMR_710_15

GA Baker, A Jacoby, D Buck, C Stalgis, and D Monnet. Quality of life of people with epilepsy: A European study. Epilepsia; 1997. 38(3):353–362. DOI: 10.1111/j.1528-1157.1997.tb01128.x

Cramer JA, Mintzer S, Wheless J, & Mattson RH. Adverse effects of antiepileptic drugs: A brief overview of important issues. Expert Review of Neurotherapeutics; 2007. 10(6):885–891. DOI: 10.1586/ern.10.71

Banerjee N, Filippi D. and Hausser A. The descriptive epidemiology of epilepsy : A review. Epilepsy Res; 2009. 85(1):31–45.

DOI: 10.1016/j.eplepsyres.2009.03.003

Lancet N. Global, regional, and national burden of epilepsy, 1990 – 2016 : A systematic analysis for the global burden of disease study. Lancet Neurol; 2019. DOI: 10.1016/S1474-4422(18)30454-X

Canpolat M. et al. Prevalence and risk factors of epilepsy among school children in Kayseri City Center, An urban area in Central Anatolia, Turkey. Seizure: European Journal of Epilepsy. BEA Trading Ltd; 2014. 23(9):708–716.

DOI: 10.1016/j.seizure.2014.05.012.

Amudhan S, Gururaj G, Satishchdanra P. Epilepsy in India I: Epidemiology dan public health. Ann Indian Acad Neurol; 2015. 18:268-77. Available from:

Shetty PH. et al. Quality of life in patients with epilepsy in India. J Neurosci Rural Pract; 2011. 2(1):33–40. DOI: 10.4103/0976-3147.80092

Ayalew MB. Patient reported adverse events among epileptic patients taking antiepileptic drugs. SAGE Open Med; 2018. DOI: 10.1177/2050312118772471

Perucca P, Carter J, Vahle V. Adverse Antiepileptic Drug Effects. Epilepsy Currents; 2010. 10(1):11–12. DOI: 10.1111/j.1535-7511.2009.01339.x

Goldenberg MM. Overview of drugs used for epilepsy and seizures etiology, diagnosis, and treatment; 2010. 35(7). Available from:


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