FACTORS AFFECTING PROGNOSIS OF TUBERCULOUS MENINGITIS IN SAIFUL ANWAR GENERAL HOSPITAL MALANG

Authors

  • Badrul Munir Neurology Department, Medical Faculty of Brawijaya university
  • Firman Prayudi Neurology Department, Medical Faculty of Brawijaya university
  • Catur Ari Setianto Neurology Department, Medical Faculty of Brawijaya university
  • Siswanto . Public Health Department Medical Faculty of Brawijaya University

Keywords:

Neuroinfection

Abstract

Background. The mortality rate of tuberculous meningitis (TBM) is approximately 20-41%. The prognosis is influenced by clinical and radiologic features, laboratory findings, and therapy.

Objective. To report factors affecting the prognosis of TBM patients in Saiful Anwar Hospital.

Methods. The study design was a retrospective cohort with consecutive sampling. Data were taken from medical records of 47 patients from 2016-2017. The prognostic value used modified rankin scale showing good (0-2) and poor prognosis (3-6). The impact of clinical, radiological, and laboratory factors were investigated by univariate analysis and multiple logistic regression. 

Results. In this study, good (n=21) and bad (n=26) prognosis were compared. Patients with good prognosis experienced more episodes of seizure than poor prognosis (17% vs 4%; p = 0.011). Focal neurologic deficits was more prevalent in poor prognosis (4% vs. 23%, p = 0.012). Meningeal enhancement was more common in poor prognosis (21% vs 42%; p= 0.038). From multivariate analysis, we found that seizure and focal neurological deficit are independent prognostic factors (p=0.023 dan p 0.033).

Conclusion. Clinical factors influencing prognosis of TBM in Saiful Anwar Hospital are seizure and focal neurological deficit. Focal neurological deficit is a poor prognostic factor. However, seizure is a good prognostic factor. 

 Keywords: prognostic factors, tuberculous meningitis

Author Biographies

Badrul Munir, Neurology Department, Medical Faculty of Brawijaya university

neurology department brawijaya university

Firman Prayudi, Neurology Department, Medical Faculty of Brawijaya university

neurology department brawijaya university

Catur Ari Setianto, Neurology Department, Medical Faculty of Brawijaya university

neurology department brawijaya university

Siswanto ., Public Health Department Medical Faculty of Brawijaya University

Public Health Department Brawijaya University

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Published

2020-01-30

How to Cite

Munir, B., Prayudi, F., Setianto, C. A., & ., S. (2020). FACTORS AFFECTING PROGNOSIS OF TUBERCULOUS MENINGITIS IN SAIFUL ANWAR GENERAL HOSPITAL MALANG. MNJ (Malang Neurology Journal), 6(1), 1–4. Retrieved from https://mnj.ub.ac.id/index.php/mnj/article/view/356

Issue

Vol. 6 No. 1 (2020): January

Section

Research Article

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