Ully Husna, Mochamad Dalhar
  MNJ, pp. 94-107  


Cerebral edema comprehensively defined as a pathological increase of water in the whole brain that leads to an increased of brain volume. Cerebral edema can be classified into focal or global topography. According to the etiology, it can be categorized as cytotoxic, vasogenic, interstitial, or a combination. The symptoms of cerebral edema are not specific and are associated with secondary effects of mass, vascular compression and herniation. Clinical and radiological changes are usually reversible in the early stages during the underlying cause is corrected. Cerebral edema need to be discussed more specifically in the pathophysiology and management. By understanding the pathophysiology and management quickly and accurately will be able to improve the prognosis of patients with cerebral edema.


cerebral edema; cytotoxic; vasogenic; interstitial

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Abe T, et al. Oxidative metabolism in cultured rat astroglia: effects of reducing the glucose concentration in the culture medium and of D-aspartate or potassium stimulation. Journal of Cerebral Blood Flow & Metabolism 2006; 26:153–160.

Soeatmadji, DW. Obesity, Insulin Resistance, and The Brain The Next Target. Brawijaya University. Malang. 2013.

Ballabh P, et al. The blood–brain barrier: an overview Structure, regulation, and clinical implications, Departments of Pediatrics, Anatomy and Cell Biology, and Pathology. Neurobiology of Disease 2004; 16:1-13.

Kaal ECA, Vecht CJ. The management of brain edema in brain tumors. Curr Opin Oncol 2004; 16:593–600.

Papadopoulos MC. Molecular Mechanism Of Brain Tumor Edema. Neuroscience 2004;129:1011–1020.

Song EC, et al. Hyperglycemia Exacerbates Brain Edema and Perihematomal Cell Death After Intracerebral Hemorrhage. Stroke 2005; 34:2215-2220.

Xi G, et al. Mechanisms of Edema Formation After Intracerebral Hemorrhage: Effects of Extravasated Red Blood Cells on Blood Flow and Blood-Brain Barrier Integrity. Stroke. 2005; 32:2932-2938.

Simard JM, et al. Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications. Lancet Neurol 2007; 6(3):258–268.

Puri SK, et al. Cerebral Edema and its Management. MJAFI 2005; 59: 326-331.

Rabinstein AA. Treatment of Cerebral Edema. The Neurologist 2006; 12: 59–73.

Da Silva, JC. Hypertonic saline more efficacious than mannitol in lethal intracranial hypertension model. Neurologycal Research. 2009.

Susanti I. Handryastuti RA. Perbandingan Efektifitas Salin Hipertonik dan Manitol pada Anak dengan Edema Serebri. CDK 200 2013;40:1.

Bullock MR, Povlishock JT. Guidelines for the Management of severe traumatic Brain injury 3rd Edition. Journal of Neurotrauma 2007;24.

Parra, A. Adult Neurocritical Care Protocols “Hypertonic Saline”. Department of Neurosurgery. UTHSCSA. 2008.

Helbok R, et al. Global Cerebral Edema and Brain Metabolism After Subarachnoid Hemorrhage. Stroke 2011; 42:1534-1539.

Donkin JJ, Vink R. Mechanisms of cerebral edema in traumatic brain injury: therapeutic developments. Curr Opin Neurol 2010; 23:293–299.


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