RELATIONSHIP BETWEEN THE RANDOM BLOOD GLUCOSE LEVELS DURING ADMISSION AT EMERGENCY ROOM WITH CLINICAL OUTPUT IN ACUTE ISCHEMIC STROKE PATIENTS

Authors

  • Badrul Munir Laboratorium Neurologi Fakultas Kedokteran Universitas Brawijaya, Malang
  • Harun Al Rasyid Laboratorium Ilmu Kesehatan Masyarakat Fakultas Kedokteran Universitas Brawijaya, Malang
  • Rizky Rosita Program Studi Pendidikan Dokter Fakultas Kedokteran Universitas Brawijaya, Malang

Keywords:

Acute Ischemic Stroke, Blood Glucose Level, NIHSS, Outcome, Improvement

Abstract

Background. High blood glucose level occurs on 20-50% acute ischemic stroke patients. Hyperglycemia can worsen neurology disorder of patients.
Objective. To find out the relationship between random blood glucose level and clinical outcome on patients with acute ischemic stroke measured with NIHSS.
Methods. Observational using stroke registry of acute ischemic stroke patients. There are 38 patients involved in this research.
Results. Using Spearman shows an insignificant correlation between random blood glucose level and NIHSS output (p=0.548). However, random blood glucose level and NIHSS input shows a significant correlation (p=0.011). The result of Chi-Square test on correlation between random blood glucose level and NIHSS output shows an insignificant correlation (p=1), in contrast, random blood glucose level and NIHSS input and improvement shows a significant correlation (p=0.024 and p=0.047).
Conclusion. There is no correlation between random blood glucose level at initial care and clinical outcome on patients suffering acute ischemic stroke. However, normal random blood glucose level shows had better improvement and they had tendency to get better outcome.

References

Alvarez-Sabin, J., Molina, C. A., Montaner, J., Arenillas, J. F., Huertas, R., Ribo, M., et al. Effects of Admission Hyperglycemia on Stroke Outcome in Reperfused Tissue Plasminogen Activator-treated Patients. Stroke. 2003. 34;1235–1241.

Alvarez-Sabin, J., Molina, C. A., Montaner, J., Arenillas, J. F., Huertas, R., Ribo, M., et al.. Impact of Admission Hyperglycemia on Stroke Outome After Thrombolysis. 2004.35;2493.

Bhagavan, N.V. Medical Biochemistry 4th Ed. Canada: Harcourt Academic Press. 2002.

Bravata, D.M., Kim N., Concato J., Brass L.M. Hyperglycaemia in Patients with Acute Ischaemic Stroke: How Often Do We Screen for Undiagnosed Diabetes? Q J Med. 2003. 96; 491-497.

Burhanuddin, M., Wahiduddin, Jumriani. 2012. Faktor Resiko Kejadian Stroke pada Dewasa Awal (18-40) di Kota Makassar Tahun 2010-2012. Diperoleh tanggal 5 Desember 2013 dari http://repository.unhas.ac.id

Departemen Kesehatan Republik Indonesia. Risiko Utama Penyakit Tidak Menular Disebabkan Rokok. Jakarta: Kementrian Kesehatan Republik Indonesia. 2013.

Dinata, C.A., Safrita, Y., Sastri, S.G. Gambaran Faktor Risiko dan Tipe Stroke pada Pasien Rawat Inap di Bagian Penyakit dalam RSUD Kabupaten Solok Selatan Periode 1 Januari 2010–31 Juni 2012. 2012. Diperoleh 5 Juli 2014 dari http//:Repository.unri.ac.id

Gentile, N.T., Michael, W., Seftchick, B.S., Huynh, B.S.T, Linda, K., Kruus, et al. Decreased Mortality by Normalizing Blood Glucose after Acute Ischemic Stroke. 2006 13(2):174.

George, B. Kapita Selekta Neurologi. Edisi ke2. Yogyakarta: Gadjah Mada University Press, 2011. pp:86-88

Guven, H., Cilliler, A.E., Sarikaya, S.A., Koker, C., Comoglu, S.S. The Etiologicand Prognostic Importance of High Leukocyte and Neutrophill Counts in AcuteIschemic Stroke. Turkish: Journal of Neurological Sciences. 2010. 27;3:311-318

Hasibuan, A.E., Fithrie, A., Sinurat, P.P.O., Nasution, D. Nilai Prognostik Kadar Gula Darah Kapiler dan Tekanan Darah terhadap Keluaran Stroke Iskemik Akut. Medan: Majalah kedokteran Neurona. 2014.

Heart and Stroke Foundation. A Perfect Storm of Heart Disease Looming on Our Horizon. 2010. Diperoleh tanggal 8 Desember 2013. www.heartandstroke.com

Iqbal, M., Fridaz, M., Yaswira, R. Perbedaan Rerata Kadar Gula Darah pada Luaran Stroke Iskemik Berdasarkan Indeks Barthel. Padang: Jurnal Kesehatan Andalas. 2014.

Irdawati, Ambarwati, W.N. Hubungan antara Pengetahuan dan Sikap Keluarga dengan Perilaku dalam MeningkatkanKapasitas Fungsional Pasien Pasca Stroke di Wilayah Kerja Puskesmas Kartasura. 2009. Diperoleh tanggal 5 Juli 2014 dari https://Publikasiilmiah.ums.ac.id.

Irfan, M. Fisioterapi Bagi Insan Stroke. Yogyakarta: Graha Ilmu. 2010.

Kagansky, N., Levy, S., Knobler, H. The Role of Hyperglycemia in Acute Stroke. Arch Neurol. 2001. 58;1209-1212.

Li, P.A., Shuaib, A., Miyashita, H., He, Q.P., Siesjo, B.K. Hyperglycemia Enhances Extracellular Glutamate Accumulation in Rats Subjected to Forebrain Ischemia. Stroke. 2000.; 31 :63.

Lingga, L. All About Stroke : Hidup sebelum dan pasca stroke. Jakarta: Elex Media Komputindo. 2013.

Lloyd-Jones, D., Adams, R., Carnethon, M., Simone, G., Ferguson, B., Flegal, K. 2009. Heart Disease and Stroke Statistics-2009 Update : A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 119:e21e181

Longstaff, A. Neuroendocrine Control of Metabolism and Growth. In: Neuroscience. 1st ed. Oxford: Scientific Publisher Ltd; 2000. p274-82.

Lumbantobing, S.M. 2004. Neurogeriatri. Jakarta: Balai Penerbit FKUI

Mardjono, M, Sidharta, P. Neurologi Klinis Dasar. PT Dian Rakyat. 2004.

Murray, R.K., Granner, D.K., Mayes, P.A., Rodwell, V.W. Harper`s Biochemistry. 24th Ed. USA:Simon & Schuster Company. 2006.

National Stroke Association. What is stroke. (Online). 2012. http://www.stroke.org/site/PageServer?pagename=stroke, diakses 10 Desember 2012.

Parsons, M.W., Barber, P.A., Desmond, P.M., Baird, T.A., Darby, D.G., Byrnes, G., et al. 2002. Acute Hyperglycemia Adversely Affects Stroke Outcome: A Magnetic Resonance Imaging and Spectroscopy Study. Annals of Neurology, 52, 20–28.

Sidharta, P. Neurologi Klinis dalam Praktek Umum. Jakarta: Dian Rakyat. 2004.

Stroke Association. Stroke Statistics (Online). http://www.stroke.org.uk/resourcesheet/stroke-statistics, diakses pada tanggal 30 Desember 2013. 2013.

Wahjoepramono, E.J. Stroke Tata Laksana Fase Akut. Jakarta: Universitas Pelita Harapan. 2005.

Weir, C.J., Murray, G.D., Dyker, A.G., Lees, K.R. 1997. Is Hyperglycaemia an Independent Predictor of Poor Outcome After Acute Stroke? Results of A Long Term Follow Up Study. BMJ. 314:1303.

Yanis, H. 2004. Pola Kadar Glukosa Darah pada Stroke Akut. Tesis: Program Pendidikan Pasca Sarjana Universitas Diponegoro. Diambil tanggal 7 desember 2014. http://eprints.undip.ac.id/12330/

Downloads

Published

2015-06-01

How to Cite

Munir, B., Rasyid, H. A., & Rosita, R. (2015). RELATIONSHIP BETWEEN THE RANDOM BLOOD GLUCOSE LEVELS DURING ADMISSION AT EMERGENCY ROOM WITH CLINICAL OUTPUT IN ACUTE ISCHEMIC STROKE PATIENTS. MNJ (Malang Neurology Journal), 1(2), 52–60. Retrieved from https://mnj.ub.ac.id/index.php/mnj/article/view/21

Issue

Section

Research Article