Badrul Munir, Didi Candradikusuma
  MNJ, pp. 7-11  


Background. Complications of HIV-AIDS cases neurological disorders are quite high and also very high mortality, but so far the data on disease epidemiology in Indonesia is still very limited.
Objective. To determine the pattern of HIV-AIDS disease involving the nervous system in patients admitted to Saiful Anwar hospital.
Methods. This prospective cohort study with a record of all patients with HIV-AIDS didagnosis manifest neurological disorders treated in an isolation room for HIV-AIDS Saiful Anwar Hospital for 1 year (September 2013- August 2014).
Results. During 12 months acquired HIV-AIDS with neurological disorders as many as 23 patients (38.3% of all patients with an infection of the nervous system) with an average age of 48 years. Male gender 47.83%) and 52.17% of women. Number of CD4+ average of 24 / microliter, while the average number of leucocytes 9675/uL, while the most common sequence of disease; 39.1% of cerebral toxoplasmosis, tuberculosis meningoencephalitis 21.7%, 17.4% viral encephalitis, bacterial meningoencephalitis 13%, 4.3% dementia, cerebral abscess 4.3%. The mortality rate is still high, ranging from 57.6%.
Conclusion. Manifestations of HIV AIDS in the field of neurology are very high, cerebral toxoplasmosis is the most common diagnosis, and correlated with the levels of CD4+. The mortality rate of HIV-AIDS cases manifesting high neurology.


AIDS; encephalitis; HIV; cerebral toxoplasmosis

Full Text:



Garvey L, Winston A, Walsh J, Post F, Porter K, Gazzard B, et al. HIV-associated central nervous sistem diseases in the recent combination antiretroviral therapy era. Eur J Neurol. Mar 2011;18(3):527-34.

Wright E. Neurocognitive impairment and neuroCART. Curr Opin HIV AIDS. Jul 2011;6(4):303-8.

Stroup JS, Stephens JR, Bury J, Hendrickson SE. Cytomegalovirus encephalitis in an HIVseropositive person. The AIDS Reader 17.3 (Mar 2007): 133-4, 136.

Akhter K dan Bronze MS. 2014. Medscape: Cytomegalovirus. 702-overview#showall diakses pada tanggal 12 Juni 2014 pukul 00.32.

Singh NN dan Roos KL. Medscape: HIVAssociated Vacuolar Myelopathy. 2013. (Online). diakses pada tanggal 11 Juni 2014 pukul 21.11.

Fernandez-Fernandez F, de Fuente-Aguado J, Ocampo-Hermida A, Iglesias-Castanon A. Remission of HIV-associated myelopathy after highly active antiretroviral therapy. Journal of Postgraduate Medicine 50.3 (JulSep 2004):195-6.

Jansen K, Haastert B, Michalik C, Guignard A, Esser S, Dupke S, et al. Incidence and risk factors of herpes zoster among hiv-positive patients in the german competence network for HIV/AIDS (KompNet): a cohort study analysis. BMC Infect Dis. 2013 Jan;13:372.

Gangneux, Florence Robert., Dardé, MarieLaure. Epidemiology of and Diagnostic Strategies for Toxoplasmosis. American Society for Microbiology. Clin. Microbiol. Rev. 2012, 25(2):264.

Ross, Karen L. Principles of Neurological Infectious Diseases.The McGraw-Hill Companies, Inc; United States of America. 2005

Manji H, Jäger HR, Winston A. HIV, dementia and antiretroviral drugs: 30 years of an epidemic. J Neurol Neurosurg Psychiatry. 2013 Oct;84(10):1126–37.

Singh N. HIV Encephalopathy and AIDS Dementia Complex [Internet]. 2013 [cited 2014 Jun 12]. Available from:

Pulido, Joss S dkk. Neuro-Oncology : Racial differences in primary central nervous sistem lymphoma incidence and survival rates. 2008. Departments of Neurology and Neurosurgery,University of Virginia Health Sistem, Charlottesville, VA (D.S.); USA

Knudsen RP dan Roos KL. 2013. Medscape: Overview of Syphilis of the CNS. (diakses pada tanggal 8 Juni 2014 pukul 22.25).

Pulido, Joss S dkk. Neuro-Oncology : Racial differences in primary central nervous sistem lymphoma incidence and survival rates.2008. Departments of Neurology and Neurosurgery,University of Virginia Health Sistem, Charlottesville, VA (D.S.); USA.

Ramizes-Crescencio MA et al, epidemiology and trend of neurological disease association to HIV AIDS experience of Mexican patient 1995-2009 Clin Neurolsurgery Jan 28 2013

Amuta E U, Amal O, |Houmsou RS, Toxoplasma gondii IgG antibodies in HIV/AIDS patients attendeing hospital in Makurdi metropolis, Benua State, Nigeria Int J Med Biomed d Res 2012; 19; 186-192

Fransiska , Kelainan Sistem saraf Pusat pada pasien HIV/AIDS yang di Rawat Inap di Rumah sakit Imanuel bandung Periode Januari 2007-Desember 2008.

Efsen AM et al, TB Meningitis in HIV-Positive pasients in Europe and Argentina: Clinical Outcome and Faktor associated with mortality; Biomed Res Int 2013;373601


  • There are currently no refbacks.