COMPARISON OF COGNITIVE FUNCTION BETWEEN FIRST ISCHEMIC STROKE AND RECURRENT ISCHEMIC STROKE PATIENTS

Authors

  • Fildza Intan Rizkia Universitas Padjadjaran, Bandung, Indonesia
  • Chandra Calista Department of Neurology, Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung, Indonesia
  • Suryani Gunadharma Department of Neurology, Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung, Indonesia
  • Asep Nugraha Hermawan Department of Neurology, Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung, Indonesia
  • Lisda Amalia Department of Neurology, Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung, Indonesia
  • Paulus Anam Ong Department of Neurology, Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung, Indonesia

DOI:

https://doi.org/10.21776/ub.mnj.2022.008.01.7

Keywords:

Cognitive function, first ischemic stroke, recurrent ischemic stroke

Abstract

Background: Cognitive impairment is a common condition that may affect up to 50% of stroke patients. Post stroke cognitive impairment is associated with reduced quality of life, which may increase the number of dependency. Recurrent stroke may happen in approximately 25% patients and they have higher rates of cognitive impairment.Objective: The aim of this study is to examine the comparison of cognitive function between first ischemic stroke and recurrent ischemic stroke patients in Hasan Sadikin Hospital, Bandung.Methods: This study is a retrospective, cross-sectional study using the data recruited between the year 2012 - 2016 at the Department of Neurology at the Hasan Sadikin Hospital Bandung. The data collected in this study were demographic data, including age, level of education, and residence, and the clinical data as well. Cognitive function was assessed using Mini-Mental State Examination (MMSE). The comparison between the cognitive function between both groups were analyzed using the Mann-Whitney U test.Results: There were 428 subjects eligible for this study, with 207 subjects categorized as first ischemic stroke group and 221 subjects categorized as recurrent ischemic stroke group. There was a statistically significant difference in MMSE scores between the first ischemic stroke patients (24.90 ± 4.64) and recurrent ischemic stroke patients (22.85 ± 4.64 ) with a p value of 0.002.Conclusion: Recurrent ischemic stroke patients had lower MMSE scores than the first ischemic stroke patients. Clinicians should be more aware in detecting early cognitive impairment in stroke patients and in preventing the incidence of recurrent stroke.

References

Feigin VL, Norrving B, Mensah GA. Global burden of stroke. Circ Res. 2017;120(3):439–48.

DOI: 10.1161/CIRCRESAHA.116.308413

Oza R, Rundell K, Garcellano M. Recurrent Ischemic Stroke: Strategies for Prevention. Am Fam Physician. 2017;96(7):436–40. Avalaible from: https://pubmed.ncbi.nlm.nih.gov/29094912/

Kapoor A, Lanctot KL, Bayley M, Herrmann N, Murray BJ, Swartz RH. Screening for Post-Stroke Depression and Cognitive Impairment at Baseline Predicts Long-Term Patient-Centered Outcomes After Stroke. J Geriatr Psychiatry Neurol. 2019;32(1):40–8. DOI: 10.1177/0891988718819859

Nakling AE, Aarsland D, Næss H, Wollschlaeger D, Fladby T, Hofstad H, et al. Cognitive Deficits in Chronic Stroke Patients: Neuropsychological Assessment, Depression, and Self-Reports. Dement Geriatr Cogn Dis Extra. 2017;7(2):283–96.

DOI: 10.1159/000478851

Kalaria RN, Akinyemi R, Ihara M. Stroke injury, cognitive impairment and vascular dementia. Biochim Biophys Acta - Mol Basis Dis. 2016;1862(5):915–25. DOI: 10.1016/j.bbadis.2016.01.015

Jacova C, Pearce LA, Costello R, McClure LA, Holliday SL, Hart RG, et al. Cognitive impairment in lacunar strokes: The SPS3 trial. Ann Neurol. 2012;72(3):351–62. DOI: 10.1002/ana.23733

Ng YS, Tan KHX, Chen C, Senolos GC, Koh GCH. How Do Recurrent and First-Ever Strokes Differ in Rehabilitation Outcomes? Am J Phys Med Rehabil. 2016;95(10):709–17.

DOI: 10.1097/PHM.0000000000000502

Kauw F, Takx RAP, De Jong HWAM, Velthuis BK, Kappelle LJ, Dankbaar JW. Clinical and imaging predictors of recurrent ischemic stroke: a systematic review and meta-analysis. Cerebrovasc Dis. 2018;45(5–6):279–87. DOI: 10.1159/000490422

Habibi-Koolaee M, Shahmoradi L, Niakan Kalhori SR, Ghannadan H, Younesi E. Prevalence of Stroke Risk Factors and Their Distribution Based on Stroke Subtypes in Gorgan: A Retrospective Hospital-Based Study - 2015-2016. Neurol Res Int. 2018;2018.

DOI: 10.1155/2018/2709654

Ghani L, Mihardja LK, Delima D. Faktor Risiko Dominan Penderita Stroke di Indonesia. Bul Penelit Kesehat. 2016;44(1):49–58. Avalaible from: https://media.neliti.com/media/publications/20146-ID-faktor-risiko-dominan-penderita-stroke-di-indonesia.pdf

Zhao L, Biesbroek JM, Shi L, Liu W, Kuijf HJ, Chu WWC, et al. Strategic infarct location for post-stroke cognitive impairment: A multivariate lesion-symptom mapping study. J Cereb Blood Flow Metab. 2018;38(8):1299–311.

DOI: 10.1177/0271678X17728162

Khan MI. The Epidemiology of Stroke in a Developing Country (Pakistan). J Neurol Stroke. 2018;8(1). DOI: 10.15406/jnsk.2018.08.00275

Jeong HY, Jung KH, Mo H, Lee CH, Kim TJ, Park JM, et al. Characteristics and management of stroke in Korea: 2014–2018 data from Korean Stroke Registry.

Int J Stroke. 2020;15(6):619–26.

DOI: 10.1177/1747493019884517

Kitzman PH, Sutton KM, Wolfe M, Bellamy L, Dobbs MR. The Prevalence of Multiple Comorbidities in Stroke Survivors in Rural Appalachia and the Clinical Care Implications. J Stroke Cerebrovasc Dis. 2019;28(11):104358.

DOI: 10.1016/j.jstrokecerebrovasdis.2019.104358

Bergström L, Irewall AL, Söderström L, Ögren J, Laurell K, Mooe T. One-Year Incidence, Time Trends, and Predictors of Recurrent Ischemic Stroke in Sweden from 1998 to 2010: An Observational Study. Stroke. 2017;48(8):2046–51.

DOI: 10.1161/STROKEAHA.117.016815

Wahid D, Rabbani H, Inam A, Akhtar Z. A hemispheric comparison of cognitive dysfunction and sleep quality impairment in middle cerebral artery infarction. Pakistan J Med Sci. 2020;36(3).

DOI: 10.12669/pjms.36.3.1385

Mellon L, Brewer L, Hall P, Horgan F, Williams D, Hickey A, et al. Cognitive impairment six months after ischaemic stroke: A profile from the ASPIRE-S study. BMC Neurol. 2015;15(1):1–9.

DOI: 10.1186/s12883-015-0288-2

Kwon HS, Lee D, Lee MH, Yu S, Lim JS, Yu KH, et al. Post-stroke cognitive impairment as an independent predictor of ischemic stroke recurrence: PICASSO sub-study. J Neurol. 2020;267(3):688–93. DOI: 10.1007/s00415-019-09630-4

Mohd Zulkifly MF, Ghazali SE, Che Din N, Singh DKA, Subramaniam P. A Review of Risk Factors for Cognitive Impairment in Stroke Survivors. Sci World J. 2016;2016. DOI: 10.1155/2016/3456943

Harahap Herpan Syafii, Indrayana Yanna, Putri Setyawati Asih. Relationship Between Level of Education and Post-Stroke Cognitive Status in Hospital-Based Ischemic Stroke Survivors. Malang Neurology Journal, [S.l.], v. 7, n. 1, p. 1-6, dec. 2020. ISSN 2442-5001.

DOI: 10.21776/ub.mnj.2021.007.01.1

Jacquin A, Binquet C, Rouaud O, Graule-Petot A, Daubail B, Osseby GV, et al. Post-stroke cognitive impairment: High prevalence and determining factors in a cohort of mild stroke. J Alzheimer’s Dis. 2014;40(4):1029–38. DOI: 10.3233/JAD-131580

Tipnis Natasha, Rajadhyaksha Girish, Shah Meghav. Cognitive Impairment in Hypertensives. Malang Neurology Journal, [S.l.], v. 7, n. 2, p. 98-103, june 2021. ISSN 2442-5001.

DOI: 10.21776/ub.mnj.2021.007.02.3

Moon JH. Endocrine risk factors for cognitive impairment. Endocrinol Metab. 2016;31(2):185–92.

Tang HD, Zhou Y, Gao X, Liang L, Hou MM, Qiao Y, et al. Prevalence and risk factor of cognitive impairment were different between urban and rural population: A community-based study. J Alzheimer’s Dis. 2015;49(4):917–25. DOI: 10.3233/JAD-150748

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Published

2021-12-27

How to Cite

Rizkia, F. I., Calista, C., Gunadharma, S., Hermawan, A. N., Amalia, L., & Ong, P. A. (2021). COMPARISON OF COGNITIVE FUNCTION BETWEEN FIRST ISCHEMIC STROKE AND RECURRENT ISCHEMIC STROKE PATIENTS. Malang Neurology Journal, 8(1), 30–34. https://doi.org/10.21776/ub.mnj.2022.008.01.7

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Research Article