CLOSING THE GAP FOR PHARMACOLOGICAL TREATMENT OF PAINFUL DIABETIC NEUROPATHY : THE POTENTIAL ROLE OF VITAMIN D
Keywords:Painful diabetic neuropathy, vitamin D, treatment
AbstractPainful neuropathic pain is a challenging chronic pain to treat. It is heterogeneous in symptoms and could be resistant to the available treatments regimen.Â Current pharmacological treatments fail to achieve adequate pain relief in a most patients. The previous review showed that only less than 50% of patients can achieve good pain reduction with standard adjuvant treatment. The available adjuvants analgesic only focus in the symptom control, and do not interfere with the progressing damage of the nerve. Vit D insufficiency is quite frequent in type 2 diabetes patients.diabetes, particularly those with symptoms of DPN. The studies also showed that low serum vitamin D levels are an independent predictor of DPN development. Vitamin D supplementation is necessary for diabetic neuropathy patients since it promotes the synthesis of neurotrophins and neurotransmitters. Additional vitamin D therapy have big role in nerve growth factor and the regulation of neurotrophin and Ca2+ homeostasis in neurons, and provides protection for neurons in the peripheral nervous system. Â In this review, we do systematically search the studies about Vitamin D for the treatment of painful diabetic neuropathic condition. We used PubMed, Cochrane, Clinical Key, and search Google Scholar for papers that used vitamin D phrases. and painful diabetic neuropathy as our major database for thisÂ review andÂ we make a systematic table to explain our review. However, there is still an unmet need in the management of neuropathic pain. The unmet needs maybe caused by the gap between pharmacological treatmnet in pain reduction in painful diabetic neuropathy patients. Therefore, in this review we discuss about the potential use of vitamin D as an add-on therapy to closing the gap in the management of neuropathic pain.
Juster-Switlyk K, & Smith AG. Updates in diabetic peripheral neuropathy. F1000Research, 5, F1000 Faculty Rev-738; 2016.
Iqbal Z, Azmi S, Yadav R, Ferdousi M, Kumar, M, Cuthbertson DJ, et al. Diabetic peripheral neuropathy: Epidemiology, diagnosis, and pharmacotherapy. Clinical Therapeutics; 2018. 40(6):828-849.
Schreiber AK, Nones CF, Reis RC, Chichorro, JG, Cunha JM. Diabetic neuropathic pain: Physiopathology and treatment. World journal of diabetes; 2015. 6(3):432â€“444.
Kaur S, Pandhi P, Dutta P. Painful diabetic neuropathy: An update. Annals of neurosciences; 2011. 18(4):168â€“175.
Javed S, Alam U, Malik RA. Treating diabetic neuropathy: Present strategies and emerging solutions. The review of diabetic studies; 2015. 12(1-2):63â€“83. DOI: https://doi.org/10.1900/RDS.2015.12.63
Snyder MJ, Gibbs LM, Lindsay TJ. Treating painful diabetic peripheral neuropathy: An Update. American
Family Physician; 2016. 94(3):227â€“234. Avalaible from: https://pubmed.ncbi.nlm.nih.gov/27479625/
Rosenberger DC, Blechschmidt V, Timmerman H, Wolff A, Treede RD. Challenges of neuropathic pain: Focus on diabetic neuropathy. Journal of Neural Transmission; 2020. 127(4):589â€“624.
Oraby MI, Srie MA, Abdelshafy S, Elfar E. Diabetic peripheral neuropathy: The potential role of vitamin D deficiency. Egypt J Neurol Psychiatry Neurosurg; 2019. 55:10. DOI: https://doi.org/10.1186/s41983-019-0058-y
Sari A, AkdoÄŸan Altun Z, Arifoglu Karaman C, Bilir Kaya B, Durmus B. Does vitamin d affect diabetic neuropathic pain and balance? J Pain Res; 2020. 13:171-179.
Alam U, Arul-Devah V, Javed S, Malik RA. Vitamin D and diabetic complications: True or False Prophet? Diabetes Ther; 2016. 7(1):11-26.
Karonova T, Stepanova A, Bystrova A, Jude EB. High-dose vitamin d supplementation improves microcirculation and reduces inflammation in diabetic neuropathy patients. Nutrients; 2020. Aug 20;12(9):2518. DOI: 10.3390/nu12092518
Shehab D, Al-Jarallah K, Abdella N, Mojiminiyi OA, Al Mohamedy H. Prospective evaluation of the effect of short-term oral vitamin d supplementation on peripheral neuropathy in type 2 diabetes mellitus. Med Princ Pract; 2015. 24(3):250-256.
Alam U, Fawwad A, Shaheen F, Tahir A, Basit A, Malik RA, Improvement in neuropathy specific quality of life in patients with diabetes after vitamin D supplementation. Journal of Diabetes Research; 2017. DOI: 10.1155/2017/7928083
Nadi M, Marandi SM, Esfarjani F, Saleki M, Mohammadi M. The comparison between effects of 12 weeks combined training and vitamin d supplement on improvement of sensory-motor neuropathy in type 2 diabetic women. Adv Biomed Res; 2017. 6:55.
Ghadiri-Anari A, Mozafari Z, Gholami S, Khodaei SA, Aboutorabi-Zarchi M, Sepehri F, et al. Dose vitamin D supplementations improve peripheral diabetic neuropathy? A before-after clinical trial. Diabetes Metab Syndr; 2019. Jan-Feb;13(1):890-893. DOI: 10.1016/j.dsx.2018.12.014. Ep
Pinzon, RT, Gelgel PCS. The correlation between vitamin D deficiency and the severity of painful diabetic neuropathy in patients with type 2 diabetes mellitus (T2DM). Jurnal Gizi Klinik Indonesia, [S.l]; 2020 p. 9-14.
Lee P, Chen R. Vitamin D as an analgesic for patients with type 2 diabetes and neuropathic pain. Arch Intern Med; 2008. Apr 14;168(7):771-2.
DOI: 10.1001/archinte.168.7.771. PMID: 18413561.
Basit A, Basit KA, Fawwad A, Shaheen F, Fatima N, Petropoulos IN, et al. Vitamin D for the treatment of painful diabetic neuropathy. BMJ Open Diabetes Res Care; 2016. Feb 10;4(1):e000148.
Shipton EA, Shipton EE. Vitamin D and pain: Vitamin D and its role in the aetiology and maintenance of chronic pain states and associated comorbidities. Pain Res Treat; 2015.
Faye PA, Poumeaud F, Miressi F, Lia AS, Demiot C, Magy L, et al. Focus on 1,25-Dihydroxyvitamin D3 in the peripheral nervous system. Front Neurosci; 2019. Apr 12;13:348. DOI: 10.3389/fnins.2019.00348. PMID: 31031586; PMCID: PMC6474301.
Habib AM, Nagi K, Thillaiappan NB, Sukumaran V, Akhtar S. Vitamin D and its potential interplay with pain signaling pathways. Front Immunol; 2020. 11:820. Published 2020 May 28.
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