SEIZURES IN CHILDREN WITH LOW GRADE GLIOMA

Piyush Ostwal, Shanbhag Nandan
  MNJ, pp. 60-65  

Abstract


Seizures are a common presentation of pediatric brain tumors. The incidence of pediatric brain tumor (Age 0-19 years) ranges from 1.12–5.26 cases per 100,000 persons. Low grade gliomas are an important subgroup of pediatric brain tumors causing epilepsy. Low-grade gliomas are largely slow-growing tumors and the manifestations are dependent on age, location, tumor type, size of tumor and rate of tumor growth. Seizures have been reported in up to 38 % of children with supratentorial tumors. The tumors are identified when work up of patients for epilepsy includes electrophysiological and imaging studies. The primary treatment modality remains surgical excision. Antiepileptic medications are used for control of seizures. Subsequent histopathological diagnosis is important for prognostication. The tumors commonly associated with long-term epilepsy in various studies were ganglioglioma, dysembryoplastic neuroepithelial tumor, pilocytic astrocytoma and pilocytic xanthoastrocytoma. The outcome of surgery with regards to seizure control is generally good. Though concomitantly antiepileptic medications will be needed for most of them.  An attempt is made in this review to summarize the epidemiology, clinical features, pathology and treatment aspects of pediatric low grade gliomas presenting with seizures.


Keywords


Seizures, Low grade glioma, Pediatric epilepsy, brain tumor

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References


Vinci M, Burford A, Molinari V, Kessler K, Popov S, Clarke M, et al. Functional diversity and cooperativity between subclonal populations of pediatric glioblastoma and diffuse intrinsic pontine glioma cells. Nature Medicine. 2018 Aug;24(8):1204–15. DOI: 10.1038/s41591-018-0086-7

Duan W, Wang L, Li K, Wang W, Zhan Y, Zhang F, et al. IDH mutations but not TERTp mutations are associated with seizures in lower-grade gliomas: Medicine. 2018 Dec;97(50):e13675.

DOI: 10.1097/MD.0000000000013675

Zhou W, Ke SQ, Huang Z, Flavahan W, Fang X, Paul J, et al. Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth. Nature Cell Biology. 2015 Feb;17(2):170–82.

DOI: 10.1038/ncb3090

Johnson A, Severson E, Gay L, Vergilio J, Elvin J, Suh J, et al. Comprehensive Genomic Profiling of 282 Pediatric Low‐ and High‐Grade Gliomas Reveals Genomic Drivers, Tumor Mutational Burden, and Hypermutation Signatures. The Oncologist. 2017 Dec;22(12):1478–90.

DOI: 10.1634/theoncologist.2017-0242

Bernardino MRA, Funayama C, Hamad APA, Machado H, Sakamoto A, Thome U, et al. Refractory epilepsy in children with brain tumors. The urgency of neurosurgery. Arquivos de Neuro-Psiquiatria. 2016 Dec;74(12):1008–13. DOI: 10.1590/0004-282x20160157

Ramantani G, Stathi A, Brandt A, Strobl K, Schubert-Bast S, Wiegand G, et al. Posterior cortex epilepsy surgery in childhood and adolescence: Predictors of long-term seizure outcome. Epilepsia. 2017 Mar;58(3):412–9. DOI: 10.1111/epi.13654

Ertürk Çetin Ö, İşler C, Uzan M, Özkara Ç. Epilepsy-related brain tumors. Seizure. 2017 Jan;44:93–7.

DOI: 10.1016/j.seizure.2016.12.012

Armstrong GT, Conklin HM, Huang S, Srivastava D, Sanford R, Ellison DW, et al. Survival and long-term health and cognitive outcomes after low-grade glioma. Neuro-Oncology. 2011 Feb;13(2):223–34.

DOI: 10.1093/neuonc/noq178

Wilne S, Collier J, Kennedy C, Koller K, Grundy R, Walker D. Presentation of childhood CNS tumours: a systematic review and meta-analysis. The Lancet Oncology. 2007 Aug;8(8):685–95.

DOI: 10.1016/S1470-2045(07)70207-3

Johnson KJ, Cullen J, Barnholtz-Sloan JS, Ostrom QT, Langer CE, Turner MC, et al. Childhood Brain Tumor Epidemiology: A Brain Tumor Epidemiology Consortium Review. Cancer Epidemiology Biomarkers & Prevention. 2014 Dec 1;23(12):2716–36. DOI: 10.1634/theoncologist.2017-0242

Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, et al. The 2007 WHO Classification of Tumours of the Central Nervous System. Acta Neuropathologica. 2007 Jul 12;114(2):97–109. DOI: 10.1007/s00401-007-0243-4

SEER Cancer Statistics Review, 1975-2015 [Internet]. National Cancer Institute. Bethesda, MD; Available from: https://seer.cancer.gov/csr/1975_2015/

Ullrich NJ, Pomeroy SL, Kapur K, Manley PE, Goumnerova LC, Loddenkemper T. Incidence, risk factors, and longitudinal outcome of seizures in long-term survivors of pediatric brain tumors. Epilepsia. 2015 Oct;56(10):1599–604. DOI: 10.1111/epi.13112

Fattal-Valevski A, Nissan N, Kramer U, Constantini S. Seizures as the Clinical Presenting Symptom in Children with Brain Tumors. Journal of Child Neurology. 2013 Mar;28(3):292–6.

DOI: 10.1177/0883073812445786

Luyken C, Blümcke I, Fimmers R, Urbach H, Elger CE, Wiestler OD, et al. The spectrum of long-term epilepsy-associated tumors: long-term seizure and tumor outcome and neurosurgical aspects. Epilepsia. 2003 Jun;44(6):822–30. DOI: 10.1046/j.1528-1157.2003.56102.x

Fallah A, Weil AG, Sur S, Miller I, Jayakar P, Morrison G, et al. Epilepsy surgery related to pediatric brain tumors: Miami Children’s Hospital experience. Journal of Neurosurgery: Pediatrics. 2015 Dec;16(6):675–80. DOI: 10.3171/2015.4.PEDS14476

Uliel-Sibony S, Kramer U, Fried I, Fattal-Valevski A, Constantini S. Pediatric temporal low-grade glial tumors: epilepsy outcome following resection in 48 children. Childs Nerv Syst. 2011 Sep;27(9):1413–8. DOI: 10.1007/s00381-011-1454-5

Kopinja J, Sevilla RS, Levitan D, Dai D, Vanko A, Spooner E, et al. A Brain Penetrant Mutant IDH1 Inhibitor Provides In Vivo Survival Benefit. Scientific Reports [Internet]. 2017 Dec [cited 2019 Aug 26];7(1). Available from: http://www.nature.com/articles/s41598-017-14065-w

Vecht CJ, van Breemen M. Optimizing therapy of seizures in patients with brain tumors. Neurology. 2006 Dec 26;67(Issue 12, Supplement 4):S10–3.

DOI: 10.1212/WNL.67.12_suppl_4.S10

Sherman JH, Moldovan K, Yeoh HK, Starke RM, Pouratian N, Shaffrey ME, et al. Impact of temozolomide chemotherapy on seizure frequency in patients with low-grade gliomas: Clinical article. Journal of Neurosurgery. 2011 Jun;114(6):1617–21. DOI: 10.3171/2010.12.JNS101602

Raisa N, Marhaendraputro EA. The side effects of chemotherapy in glioma. Malang Neurology Journal; 2019. May 2;5(2):92–7.

DOI: 10.21776/ub.mnj.2019.005.02.9


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