I Putu Eka Widyadharma, Nicholas Prathama Limalvin, I Made Pramana Dharmatika, Gayathridayawasi G, Ida Ayu Sri Indrayani, Boya Nugraha
  MNJ, pp. 129-133  


Industrial revolution 4.0 has changed the health industry. Medical treatments derived from the latest technologies are expected to improve health and economic status. The rapid development of technology has influenced the learning and clinical practice of medicine. Virtual Reality (VR) is one of the latest technologies that is currently being implemented as a treatment for neurological disorders. This article seeks to give an overview of the development of VR implementation in neurorehabilitation. The data source of this article is research and studies published in NCBI, PubMed, Cochrane, and other relevant online databases. From this article, it is found that VR can be used as a pain reliever and motor function rehabilitation for patients with balance and gait deficits. VR is used to distract patients’ attention to pain for a short time period. VR also improves motor function recovery in stroke patients. Cybersickness is usually reported as a side effect of using VR and it depends on each individual. The implementation of VR for patients with neurological disorders has showed advantages in reducing pain and improving motor function but still need further research about applicability and authorization of virtual reality in the world of medicine.


Industrial Revolution 4.0; Virtual Reality; Neurological Disorders

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Jai-Yon L, Jae-Young L. The prospect of the fourth industrial revolution and home healthcare in super-aged society. J Korean Geriatr Soc; 2017. 21(3):95–100. DOI: 10.4235/agmr.2017.21.3.95

Chiuchisan I, Geman O. An approach of a decision support and home monitoring system for patients with neurological disorders using internet of things concepts faculty of electrical engineering and computer science. Wseas Trans Syst; 2014. 13:460–9. Avalaible from:

Rojko A. Industry 4.0 concept: Background and overview. Special Focus Paper; 2017. Vol. 11.


Xu Li Da, Xu EL, Li L. Industry 4.0: State of the art and future trends. Int J Prod Res; 2018. 56(8):2941–62. DOI: 10.1080/00207543.2018.1444806

Müller O, Rotter S. Neurotechnology: Current developments and ethical issues. Front Syst Neurosci; 2017. 27(3):135–40. DOI: 10.3389/fnsys.2017.00093

Perez-Marcos D. Virtual reality experiences, embodiment, videogames and their dimensions in neurorehabilitation. J Neuroeng Rehabil; 2018. 15(113):1–8. Avalaible from:

Lucca LF, Candelieri A, Pignolo L. Application of virtual reality in neuro-rehabilitation: an overview. In: Kim J-J, editor. Virtual Reality. 1st ed. IntechOpen; 2011. p. 429–42. DOI: 10.5772/13555

Li A, Montaño Z, Chen VJ, Gold JI. Virtual reality and pain management: Current trends and future directions. Pain Manag; 2011. 1(2):147–57.

Pourmand A, Davis S, Marchak A, Whiteside T, Sikka N. Virtual Reality as a clinical tool for pain management. Curr Pain Headache Rep; 2018. 22(53):1–6. DOI: 10.2217/pmt.10.15

Li L, Yu F, Shi D, Shi J, Tian Z, Yang J, et al. Application of virtual reality technology in clinical medicine. Am J Transl Res; 2017. 9(9):3867–80. Avalaible from:

Samadbeik M, Yaaghobi D, Bastani P, Abhari S, Rezaee R, Garavand A. The applications of virtual reality technology in medical groups teaching. J Adv Med Educ Prof; 2018. 6(3):123–9. Avalaible from:

Ekstrand C, Jamal A, Nguyen R, Kudryk A, Mann J, Mendez I. Immersive and interactive virtual reality to improve learning and retention of neuroanatomy in medical students: A randomized controlled study. C Open; 2018;6(1):E103–9. DOI: 10.9778/cmajo.20170110

Kellmeyer P. neurophilosophical and ethical aspects of virtual reality therapy in neurology and psychiatry. Cambridge Q Healthc Ethics; 2018. 27(4):610–27. DOI: 10.1017/S0963180118000129

Stasieñko A, Sarzyńska-Długosz I. Virtual reality in neurorehabilitation. Postep Rehabil; 2016;4:67–75.

Kumar KH, Elavarasi P. Definition of pain and classification of pain disorders. J Adv Clin Res Insights; 2016. 3(3):87–90.

DOI: 10.15713/INS.JCRI.112

Fine PG, Lessage P, Lippe PM, Lipman AG, Portenoy RK. Module 1 pain management : Pathophysiology of pain and pain assessment. Am Med Assoc; 2010;1–12

Jones T, Moore T, Choo J. The impact of virtual reality on chronic pain. PLoS One; 2016. 11(12):1–10. DOI:

Garrett B, Taverner T, McDade P. Virtual reality as an adjunct home therapy in chronic pain management: An exploratory study. JMIR Med Informatics; 2017. 5(2):e11. DOI: 10.2196/medinform.7271

Indovina P, Barone D, Gallo L, Chirico A, De Pietro G, Giordano A. Virtual Reality as a Distraction Intervention to Relieve Pain and Distress during Medical Procedures. Clin J Pain; 2018. 34(9):858–77. DOI: 10.1097/AJP.0000000000000599

Porras DC, Siemonsma P, Inzelberg R, Zeilig G, Plotnik M. Advantages of virtual reality in the rehabilitation of balance and gait: Systematic review. Am Acad Neurol; 2018. 90(22):1–9.

DOI: 10.1212/WNL.0000000000005603

Massetti T, da Silva TD, Crocetta TB, Guarnieri R, de Freitas BL, Bianchi Lopes P, et al. The clinical utility of virtual reality in neurorehabilitation: A systematic review. J Cent Nerv Syst Dis; 2018. 10:117957351881354.

DOI: 10.1177/1179573518813541

Lee HS, Park YJ, Park SW. The effects of virtual reality training on function in chronic stroke patients: A systematic review and meta-analysis. Biomed Res Int; 2019. 2019:1–12. DOI: 10.1155/2019/7595639

Wardani R, Salsabila S, Novrianto Rahman A, Rakhmatiar R. Effectivity of nintendo wii as rehabilitation therapy in post stroke patients: A systematic review. Malang Neurol J; 2021. 7(1):56–9. DOI: 10.21776/ub.mnj.2021.007.01.1

de Rooij IJ, van de Port IG, Meijer J-WG. Effect of virtual reality training on balance and gait ability in patients with stroke: Systematic review and meta-analysis. Phys Ther; 2016;96(12):1905–18.

DOI: 10.2522/ptj.20160054

Porras DC, Sharon H, Inzelberg R, Ziv-Ner Y, Zeilig G, Plotnik M. Advanced virtual reality-based rehabilitation of balance and gait in clinical practice.

Ther Adv Chornic Dis 10; 2019. 1–16.

DOI: 10.1177/2040622319868379

O’Neil O, Fernandez MM, Herzog J, Beorchia M, Gower V, Gramatica F, et al. Virtual reality for neurorehabilitation: Insights from 3 european clinics. Am Acad Phys Med Rehabil; 2018. 10(9):1–9.

DOI: 10.1016/j.pmrj.2018.08.375

Hua Y, Qiu R, Yao W, Zhang Q, Chen X. The effect of virtual reality distraction on pain relief during dressing changes in children with chronic wounds on lower limbs. Pain Manag Nurs; 2015. 16(5):685–91. DOI: 10.1016/j.pmn.2015.03.001

Gordon NS, Merchant J, Zanbaka C, Hodges LF, Goolkasian P. Computers in human behavior interactive gaming reduces experimental pain with or without a head mounted display. Comput Human Behav; 2011. 27(6):2123–8.

Kellmeyer P. Neurophilosophical and ethical aspects of virtual reality therapy in neurology and psychiatry. Cambridge Q Healthc Ethics; 2018. 27(04):610–27. DOI: 10.1017/S0963180118000129

Malloy KM, Milling LS. The effectiveness of virtual reality distraction for pain reduction: A systematic review. Clin Psychol Rev; 2010. 30(8):1011–8.

DOI: 10.1016/j.cpr.2010.07.001

Laver K, Lange B, George S, Deutsch J, Saposnik G, Crotty M. Virtual reality for stroke rehabilitation (review). Cochrane Database Syst Rev; 2017;(11). DOI: 10.1002/14651858.CD008349.pub4.

Yamato T, Pompeu J, Pompeu S, Hassett L. Virtual reality for stroke rehabilitation. Am Phys Ther Assoc; 2016. 96(10):1508–13. DOI: 10.2522/ptj.20150539

Afsar SI, Mirzayev I, Yemisci OU, Saracgil SNC. Virtual reality in upper extremity rehabilitation of stroke patients: A randomized controlled trial. J Stroke Cerebrovasc Dis; 2018;27(12):3473–8.

DOI: 10.1016/j.jstrokecerebrovasdis.2018.08.007

De Rooij IJ, Van de Port IG, Meijer JWG. Feasibility and effectiveness of virtual reality training on balance and gait recovery early after stroke: A pilot study. Int J Phys Med Rehabil; 2017. 5(4):1–8.

DOI: 10.4172/2329-9096.1000418

Lei C, Sunzi K, Dai F, Liu X, Wang Y, Zhang B, et al. Effects of virtual reality rehabilitation training on gait and balance in patients with Parkinson’s disease: A systematic review. PLoS One; 2019. 14(11):e0224819.



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