PROFILE OF TYPE 2 DIABETES MELLITUS IN ACUTE THROMBOTIC STROKE

Authors

  • Danny Randy Jordan Medical Doctor Program Faculty of Medicine Airlangga University, Surabaya
  • Wardah Rahmatul Islamiyah Department of Neurology Faculty of Medicine Airlangga University, Surabaya
  • Jongky Hendro Prayitno Department of Internal Medicine Faculty of Medicine Airlangga University, Surabaya

Keywords:

Acute thrombotic stroke, Type 2 diabetes mellitus, Hyperglycemia

Abstract

Background: Stroke is a brain disorder in blood circulation that occur suddenly and last more than 24 hours, which is one leading cause of death in the world. One of the main risk factors of stroke is diabetes mellitus type 2. One complication is that when thrombosis occurs in the brain causing a stroke.
Objective: This study aimed to determine the profile of type 2 diabetes mellitus in patients with acute thrombotic stroke who were treated in the Neurology Department at the Hospital Dr. Soetomo.
Methods: Sampling was done with purposive sampling by observing the medical records of patients in the period of January 2014 to December 2015 based on inclusion and exclusion criterias that have
been set.
Results: Women with a history of type 2 diabetes are more exposed to acute thrombotic stroke; the age group which is most at risk for stroke is between age of 56-60 years; the average duration of DM until the occurence of stroke is 6,54 ± 4,85 years; more than two-thirds of patients come to the hospital when the acute thrombotic stroke occurs with a condition of hyperglycemia; the most common comorbid disease is hypertension; and insulin therapy is the most widely used therapy in acute thrombotic stroke patients with type 2 diabetes.
Conclusion: Managing the risk factors of stroke should prolong or prevent the incident of acute thrombotic stroke since most of the patients with type 2 diabetes mellitus came to the hospital with a condition of hyperglycemia and hypertension.

References

Sacco RL, Kasner SE, Broderick JP, Caplan LR, Connors JJ, Culebras A, et al. An Updated definition of stroke for the 21st century. Stroke; 2013.44(7):2064–89. DOI: http://dx.doi.org/10.1161/STR.0b013e318296aeca

Murphy SL, Kochanek KD, Xu J, Arias E. Mortality in the united states. NCHS Data Brief; 2015.(229):1–8. DOI: http://dx.doi.org/10.1056/NEJM184002260220306

World Health Organization. Global report on diabetes. WHO; 2016.978:88. Available from: http://www.who.int/about/licensing/%5Cnhttp://apps.who.int/iris/bitstream/10665/204871/1/9789241565257_eng.pdf

International Diabetes Federation. Annual report 2015; 2015.1–29. Available from: http://www.idf.org/sites/default/files/IDF_AnnualReport_2015_WEB.pdf

Gentile NT, Seftchick MW, Huynh T, Kruus LK, Gaughan J. Decreased mortality by normalizing blood glucose after acute ischemic stroke. Academic Emergency Medicine; 2006.13(2):174–80. DOI: http://dx.doi.org/10.1197/j.aem.2005.08.009

Al-Rubeaan, Khalid, et al. Ischemic Stroke and Its Risk Factors in a Registry-Based Large CrossSectional Diabetic Cohort in a Country Facing a Diabetes Epidemic. Journal of Diabetes Research, vol. 2016, 2016, pp. 1–9. DOI: http://dx.doi.org/10.1155/2016/4132589

Nacu A, Thomassen L, Fromm A, Bjerkreim A, Andreassen U, Naess H. Impact of diabetes mellitus on 1867 acute ischemic stroke patients. a bergen norstroke study. Journal of Research in Diabetes; 2015.Sep;:1-11. DOI: http://dx.doi.org/10.5171/2015.112104

Arboix A, Milian M, Oliveres M, García-Eroles L, Massons J. Impact of female gender on prognosis in type 2 diabetic patients with ischemic stroke. European Neurology; 2006.56(1):6–12. DOI: http://dx.doi.org/10.1159/000094249

Kanaya AM, Barrett-Connor E, Gildengorin G, Yaffe K. Change in cognitive function by glucose tolerance status in older adults. Archives of Internal Medicine; 2004.164(12):1327. DOI: http://dx.doi.org/10.1001/archinte.164.12.1327

Almdal T, Scharling H, Jensen JS, Vestergaard H. The independent effect of type 2 diabetes mellitus on ischemic heart disease, stroke, and death. Archives of Internal Medicine; 2004.Dec;164(13):1422. DOI: http://dx.doi.org/10.1001/archinte.164.13.1422

Hollander M. Incidence, risk, and case fatality of first ever stroke in the elderly population. The Rotterdam Study. Journal of Neurology, Neurosurgery & Psychiatry; 2003.Jan;74(3):317–21. DOI: http://dx.doi.org/10.1136/jnnp.74.3.317

Feigin VL, Forouzanfar MH, Krishnamurthi R, Mensah GA, Connor M, Bennett DA, et al. Global and regional burden of stroke during 1990-2010: findings from the Global Burden of Disease Study 2010. Lancet; 2014.383(9913):245–54. DOI: http://dx.doi.org/10.1016/S0140-6736(13)61953-4

Banerjee C, Moon YP, Paik MC, Rundek T, MoraMclaughlin C, Vieira JR, et al. Duration of diabetes and risk of ischemic stroke. Stroke; 2012.43(5):1212–7. DOI: http://dx.doi.org/10.1161/STROKEAHA.111.641381

Kiers L, Davis SM, Larkins R, Hopper J, Tress B, Rossiter SC, et al. Stroke topography and outcome in relation to hyperglycaemia and diabetes. Journal of Neurology, Neurosurgery & Psychiatry; 1992.;55(4):263–70. DOI: http://dx.doi.org/10.1136/jnnp.55.4.263

Capes SE, Hunt D, Malmberg K, Pathak P, Gerstein HC. Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients. Stroke; 2001.32(10):2426–32. DOI: http://dx.doi.org/10.1161/hs1001.096194

Perner A, Nielsen SE, Rask-Madsen J. High glucose impairs superoxide production from isolated blood neutrophils. Intensive Care Medicine. 2003;29(4):642–5. DOI: http://dx.doi.org/10.1007/s00134-002-1628-4

Munir B, Rasyid HA, Rosita R. Relationship between the random blood glucose levels during admission at emergency room with clinical output in acute ischemic stroke patients. Malang Neurology Journal; 2015.1:51–8. DOI: http://dx.doi.org/10.21776/ub.mnj.2015.001.02.2

Macpherson, Sarah L, et al. “Stroke and Diabetes: a Dangerous Liaison.†Brit ish Journal of Diabetes, vol.16, no. 3, 2016, p. 114. DOI: http://dx.doi.org/10.15277/bjd.2016.089.

Dandona P, James IM, Newbury PA, Woollard ML, Beckett AG. Cerebral blood flow in diabetes mellitus: evidence of abnormal cerebrovascular reactivity. British Medical Journal; 1978.2(6133):325–6. DOI: http://dx.doi.org/10.1136/bmj.2.6133.325

Kissela BM, Khoury J, Kleindorfer D, Woo D, Schneider A, Alwell K, et al. Epidemiology of ischemic stroke in patients with diabetes: the greater cincinnati/northern kentucky stroke study. Diabetes Care; 2005;28(2):355–9. DOI: http://dx.doi.org/10.2337/diacare.28.2.355

Alloubani, Aladeen, et al. Hypertension and Diabetes Mellitus as a Predictive Risk Factors for Stroke. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, vol. 12, no. 4, 2018, pp. 577–584. DOI: http://dx.doi.org/10.1016/j.dsx.2018.03.009.

Fuentes B, Ntaios G, Putaala J, Thomas B, Turc G, Díez-Tejedor E. European Stroke Organisation (ESO) guidelines on glycaemia management in acute stroke. European Stroke Journal; 2017.3(1):5–21. DOI: http://dx.doi.org/10.1177/2396987317742065

Powers WJ, Rabinstein AA, Ackerson T, Adeoye OM, Bambakidis NC, Becker K, et al. 2018 Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from

the american heart association/american stroke association. Stroke; 2018.49(3). DOI: http://dx.doi.org/10.1161/STR.0000000000000158

Tun NN, Arunagirinathan G, Munshi SK, Pappachan JM. Diabetes mellitus and stroke: A clinical update. World Journal of Diabetes; 2017.8(6):235. DOI: http://dx.doi.org/10.4239/wjd.v8.i6.235

Downloads

Published

2019-04-30

How to Cite

Jordan, D. R., Islamiyah, W. R., & Prayitno, J. H. (2019). PROFILE OF TYPE 2 DIABETES MELLITUS IN ACUTE THROMBOTIC STROKE. MNJ (Malang Neurology Journal), 5(2), 80–85. Retrieved from https://mnj.ub.ac.id/index.php/mnj/article/view/380

Issue

Section

Research Article