Billi Kinesya, Machlusil Husna, Shahdevi Nandar Kurniawan, Mochammad Ridwan
  MNJ, pp. 7-11  


Background. Polyneuropathy is the pathologic changes and functional disturbances in the peripheral nervous system. These changes manifest as sign and symptoms such as numbness, burning, allodynia, atrophy, and lose of stimulation responses. Diagnosing polyneuropathy can use electrodiagnostic method like electroneuromyography (ENMG). One of the most sensitive ENMG parameters for polyneuropathy is SNAP amplitude which can be measured at Sural Nerve.
Objective. The goal of this study is to know whether SNAP amplitude can be used to diagnose polyneuropathy.
Methods. The study design is diagnostic test in cross-sectional method.
Results. Samples were taken from 108 ENMG medical records of Neurology Department Saiful Anwar General Hospital during the whole 2014. Two variables which are compared are polyneuropathy diagnosis and SNAP amplitude. Fisher test shows significant differences between the two with p = 0.04. Diagnostic test shows sensitivity 68.3%, spesifisity 80%, positive predictive value 97.1%, and negative predictive value 20.5%.
Conclusion. There is a significant relationship between SNAP amplitude reduction with the diagnosis of polyneuropathy.


Polyneuropathy; ENMG; SNAP amplitude

Full Text:



Hughes RAC. Peripheral Neuropathy. The bmj 2002;324:466.

Torpy JM, Kincaid JL, Glass RM. Peripheral Neuropathy. JAMA. 2010;303(15):1556. doi:10.1001/jama.303.15.1556.

Bromberg MB, Smith AG. Handbook of Peripheral Neuropathy. Taylor & Francis, Boca Raton, 2005, p.7.

Martyn CN, Hughes RA. Epidemiology of Peripheral Neuropathy. J Neurol Neurosurg Psychiatry. 1997 Apr;62(4):310-8.

Bril V. Electrophysiologic testing. In: Gries FA, Cameron NE, Low PA, Ziegler D. Textbook of Diabetic Neuropathy. Stuttgart, Germany: Thieme Medical Publishers; 2003:177-84.

Spiegel MB. Electromyoneurography. American Family Physician, 1978 Nov;18(5):119-30.

Zhang YQ, Li JT, Wang TJ, Wang JL. Amplitude of Sensory Nerve Action Potential in Early Stage Diabetic Peripheral Neuorpathy: an analysis of 500 cases. Neural Regen Res. 2014;9(14):1389-1394.

Vinik AI, Bril V, Litchy WJ, Price KL, Bastyr EJ, 3rd. Sural sensory action potential identifies diabetic peripheral neuropathy responders to therapy. Muscle Nerve, Nov 2005;32(5):619625.

Sukarini P, Widyadharma PE, Purna Putra IGN, Purwa Samatra DPG. Nilai Normal Kecepatan Hantar Saraf di RSUP Sanglah Denpasar. CDK226/vol 42 no.3, 2015.

Katiriji, Bashar. Electromyography in Clinical Practice, 2nd Ed. Mosby, Elsevier, Philadelphia, PA. 2007.

Yuliawati. Perbedaan H-refleks pada pasien diabetes mellitus dengan ulkus kaki diabetik dan tanpa ulkus kaki diabetik. UGM, 2015.

Zamroni. Uji Reliabilitas dan Validitas Neuropathy Symptom Score (NSS) dan Neuropathy Deficit Score (NDS) sebagai Skor Diagnostik Neuropati Diabetik. UGM, 2013.

Buschbacher RM, Prahlow ND. Manual of nerve conduction studies, 2nd Ed. Indiana University School of Medicine Indianapolis, 2006.

Shin YB, Park JH, Kwon DR, Park BK. Variability in conduction of the lateral femoral cutaneous nerve. Muscle Nerve. 2006 May;33(5):645-9.

Saeed S, Akram M. Impact of anthropometric measures on sural nerve conduction in healthy subject. J Ayub Med Coll Abbottabad, 2008;20(4):112.

Huang CR, Chang WN, Chang HW, Tsai NW, Lu CH. Effects of age, gender, height, and weight on late responses and nerve conduction study parameters. Acta Neurologica Taiwanica 2009;18(4):242-9.


  • There are currently no refbacks.