Siti Nurlaela, Shahdevi Nandar Kurniawan, Machlusil Husna
  MNJ, pp. 1-4  


Background: Diabetic polyneuropathy (DPN) is one of the chronic complications that occur in approximately 80% of diabetes mellitus (DM) patients. This condition is a results of metabolic, vascular, and immunological disorders.
Objective: To determine the profile of electroneuromyography (ENMG) examination of DPN patients at neurology clinic of Saiful Anwar General Hospital.
Methods: This cross-sectional observational descriptive study was carried out at Saiful Anwar General Hospital Malang from June 1, 2015 to December 31, 2015, with purposive sampling method. A total of 43 DM patients with symptoms of polyneuropathy fulfilling inclusion criteria and no exclusion criteria were examined for ENMG. ENMG examirnation were including distal latency, amplitude and nerve conduction velocity of 4 motoric nerves (median, ulnar, tibial, peroneal) & 3 sensory nerves (median, ulnar, sural), and F waves of ulnar, median and peroneal nerves of the left and right extremities.
Results: Of the 43 patients evaluated in this study, the mean sensory sural nerve conduction velocity was 13.01 m/s. The majority type of nerve damage in diabetic polyneuropathy patients in this study
were mixed type (52.33% in the median nerve, 60.47% in the ulnar nerve, 72.10% in the tibial nerve, and 54.65% in the peroneal nerve in motor nerve studies and 80.23% in the median nerve and 88.37% in the peroneal nerve in the sensory nerve studies).
Conclusion: The nerve damage that occurs in DPN patients at Saiful Anwar general Hospital is severe, with the majority being the axonal demyelinating type, especially in the sensory nerve fibers in the inferior extremities.


Diabetic polyneuropathy; electroneuromyography; axonal; demyelinating

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Veves A, Malik RA. Diabetic Neuropathy Clinical Management. New Jersey: Humana Press; 2007

American Diabetes Association. 2. Classification and Diagnosis of Diabetes. Diabetes Care. 2015;38(January):S8-S16. DOI: 10.2337/dc15-S005

International Diabetes Federation. IDF Diabetes Atlas. Int Diabetes Fed. 2015:144

Said G, Goulon-Goeau C, Slama G, Tchobroutsky G. Severe Early-Onset Polyneuropathy in Insulin-Dependent Diabetes Mellitus: A Clinical and Pathological Study. The New England Journal of Medicine. 1992;326:1257-1263. DOI: 10.1056/NEJM199205073261905

Pasnoor M, Dimachkie MM, Kluding P, Barohn RJ. Diabetic Neuropathy Part 1 Overview and Symmetric Phenotypes. Neurol Clin. 2013;31:425-445. DOI: 10.1016/j.ncl.2013.02.004

Bromberg MB, Smith AG. Handbook of Peripheral Neuropathy. Boca Raton: Taylor and Francis Group; 2005

Vinik A, Ullal J, Parson HK, Casellini CM. Diabetic Neuropathies: Clinical Manifestations and Current Treatment Options. Nat Clin Pract Endocrinol Metab. 2006;2(5):269-281

Huang C, Chen T, Weng M, Lee C. Effect of Glycemic Control on Electrophysiologic Changes of Diabetic Neuropathy in Type 2 Diabetic Patients. Kaohsiung J Med Sci. 2005;21(1):15-21. DOI: http://dx.doi.org/10.1016/S1607-551X(09)70271-2

The Diabetes Control and Complications Trial Research Group. The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-term Complications in Insulin-Dependent Diabetes Mellitus. The New England Journal of Medicine. 1993;328(23):1676-1685. DOI: 10.1056/NEJM199309303291401

Pirart J. Diabetes Mellitus and Its Degenerative Complications: A Prospective Study of 4,400 Patients Observed Between 1947 and 1973. Diabetes Care. 1978;1(4):168-188

Baba M, Ozaki I. Electrophysiological Changes in Diabetic Neuropathy: from Subclinical Alterations to Disabling Abnormalities. Arch Physiol Biochem. 2001;109(3):234-240. DOI: 10.1076/apab.

Bansal V, Kalita J, Misra UK. Diabetic Neuropathy. Posgr Med J. 2006;82:95-100. DOI: 10.1136/pgmj.2005.036137

Hong CY, Chia SE, Fong SK. Neuropathy in NonInsulin-Dependent Diabetes Mellitus. The Significance of Symptoms. Scand J Prim Health Care. 2009;16(4):233-237. http://www.ncbi.nlm.nih.gov/pubmed/9932317

Katirji B, Koontz D. Disorders of Peripheral Nerves. In: Bradleys’s Neurology in Clinical Practice. Philadelphia: Elsevier; 2012

Vinik AI, Holland MT, Beau JMLE, Ljuzzi FJ, Stansberry KB, Colen LB. Diabetic Neuropathies. Diabetes Care. 1992;15(12):1926-1975

Bahou YG. A Clinical and Electrodiagnostic Study of Diabetic Neuropathy at Jordan University Hospital. Neurosciences. 2007;12(3):215-220

Bashar K. Electromyography in Clinical Practice: A Case Study Approach. USA: Elsevier; 2007

Preston DC, Shapiro BE. Electromyography and Neuromuscular Disorders. 3rd ed. United Kingdom: Elsevier Saunders; 2013

Abraham A, Alabdali M, Qrimli M, et al. Chronic Inflammatory Demyelinating Polyneuropathy Chronic Inflammatory Demyelinating Polyneuropathy in Diabetes Patients Chronic Inflammatory Demyelinating Polyneuropathy. US Neurology. 2012;11(1):47-52. DOI: http://doi.org/10.17925/USN.2015.11.01.47

UK Prospective Diabetes Study (UKPDS) Group. Effects of Intensive Blood Glucose Control with Metformin on Complications in Overweight Patients with Type 2 Diabetes (UKPDS 34). Lancet. 1998;352(Ukpds 34):854-865

Kinesya B, Husna M, Kurniawan SN, Ridwan M. Amplitudo Sensory Neuron Action Potential Using As Installation of Polyneuropathy Diagnosis. Malang Neurology Journal. 2018;4(1):7-11. DOI: http://dx.doi.org/10.21776/ub.mnj.2018.004.01.2

Purbasari B, Anggraini VL, Pratiwi MD, Husna M, Kurniawan SN. Diagnostic Test of Toronto and Modified Toronto Scoring, Monofilament Test, and Vibrate Sensation test Using 128 Hz Tuning Fork for Diabetic Polyneuropathy. Malang Neurology Journal. 2018;4(1):25-34. DOI: http://dx.doi.org/10.21776/ub.mnj.2018.004.01.5


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