CORRELATION BETWEEN LEUKOCYTE COUNT WHEN ADMITTED IN EMERGENCY ROOM (ER) WITH CLINICALLY ACUTE ISCHEMIC STROKE PATIENTS

Machlusil Husna, Kusworini Kusworini, Dian Ayu Wulansari
  MNJ, pp. 46-51  

Abstract


Background. Stroke is a local or extensive disorder of brain function that occurs suddenly and rapidly, can cause death without another cause except vascular. Based on pathophysiology of acute ischemic stroke, leukocytes play an important role against deterioration and clinical manifestations in patients by releasing three inflammatory mediators, plugging mechanism in microcirculation, and vasoconstriction.
Objective. To investigate the relationship between the clinical manifestations of acute ischemic stroke (incoming, outgoing, and improvement) as measured by the NIHSS score with the number of leukocytes .
Methods. The study design was a retrospective cohort sampling. Samples were taken from 62 patients with acute ischemic stroke (31 patients who have normal leukocytes and 31 patients who showed leukocytosis) in Dr. Saiful Anwar (RSSA) Malang hospital that met the inclusion criteria of the study.
Results. The results of the statistical test used is Kolmogorov-Smirnov test for incoming NIHSS (p = 0.999), and Chi-Square Test for outcoming NIHSS (p = 0.000) and improved patient (p = 0.001).
Conclusion. Patients who have normal leukocyte count at the beginning of treatment is likely to have clinical manifestations by category of incoming NIHSS similar to patients who showed leukocytosis, and tend to have clinical manifestations by category of outcoming NIHSS and improvement or significantly better than patients which showed leukocytosis.


Keywords


Acute Ischemic Stroke; Total leukocytes; NIHSS

Full Text:

PDF

References


WHO. 2012. Stroke, Cerebrovascular Accident. (Online). http://www.who.int/topics/cerebrovascular_accident/en/. Diakses pada 20 Desember 2013.

Centers for Disease Control and Prevention. 2009. Stroke Facts and Statistics: Division for Heart Disease and Stroke Prevention. (Online)

http://www.cdc.gov/stroke/statistical_reports.htm diakses pada 10 Desember 2013.

Departemen Kesehatan Indonesia. 2011. 8 dari 1000 Orang di Indonesia Terkena Stroke. (Online). http://www.depkes.go.id/index.php/berita/press-release/1703-8-dari-1000-orang-diindonesia-terkena-stroke.html, diakses pada 13 Desember 2013.

Clark W. Reperfusion Injury. (Online) http://www.emedicine.com/neuro/topic602.htm, diakses pada 10 Desember 2013.

Icme, Ferhat, et al. 2014. Prognostic Relationship between The Infarct Volume and Complete Blood Count in Ischemic Cerebrovascular Disease. Acta Medica. 30:529.

Denes A., Thornton P., Rothwell N. J., Allan, S. M. 2010. Inflammation and brain injury: acute cerebral ischaemia, peripheral and central inflammation.Brain, behavior, and immunity, 24(5), 708-723.

Cheng, Cheng-I., et al. 2014. The Prognostic Values of Leukocyte Rho Kinase Activity in Acute Ischemic Stroke. BioMed research international.

Gofir A. 2009. Manajemen Stroke: Evidence Based Medicine. Jogjakarta: Pustaka Cendekia Press.

Smedbakken, Linda, et al. 2011. Activated leukocyte cell adhesion molecule and prognosis in acute ischemic stroke. Stroke, 42(9), 2453-2458.

Tsai, Nai-Wen, et al. 2009. The value of leukocyte adhesion molecules in patients after ischemic stroke. Journal of neurology: 256(8), 1296-1302.

Urra, Xabier, et al. 2009. Monocytes are major players in the prognosis and risk of infection after acute stroke. Stroke: 40(4), 1262-1268.

Wu, Tzy-Haw, et al. 2013. Total white blood cell count or neutrophil count predict ischemic stroke events among adult Taiwanese: report from a community-based cohort study. BMC neurology: 13(1), 7.

Fulton R. L. 2013. Exploratory analyses to guide inclusion, limitation of sample size and strengthening of endpoints in clinical stroke trials (Doctoral dissertation, University of Glasgow).


Refbacks

  • There are currently no refbacks.