HEADACHE MANIFESTATION OF COVID-19: A CASE SERIES AND NARRATIVE REVIEW
Keywords:COVID-19, coronavirus, headache, neurologic manifestations, SARS-COV2
Despite the typical primary symptoms reported, the coronavirus disease 2019 (COVID-19) outbreak could be manifested as many symptoms. Neurological manifestations of COVID-19 are hypothesized to be caused by multiple pathophysiologies. As one of the possible prodromal symptoms in the absence of fever and respiratory symptoms, many individuals might be unaware of contracting COVID-19 infection and could possibly infect other people. This case series involved a hundred and twenty COVID-19 patients in which nine of them reported headaches as the chief complaint to provide the prevalence rate. Medical histories were assessed to provide the prevalence rate and laboratory findings of involved subjects. Narrative review of possible mechanisms of the manifestation were also denoted. To date, the proportion of non-specific manifestations as the first symptom needs to be further explored as it could be one of the initial symptoms and early manifestations of COVID-19.
Lai C, Shih T, Ko W, Tang H, Hsueh P. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges. Int J Antimicrob Agents; 2020. 17:105924.
Satgas Covid-19. Peta sebaran covid-19 [Internet]. Gugus Tugas Percepatan Penanganan Covid-19; 2020. p. 1–7. Available from: https://covid19.go.id/peta-sebaran. Accessed on: February 24, 2022.
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Articles clinical features of patients infected with 2019 novel coronavirus in Wuhan, China; 2020;497–506. DOI: 10.1016/S0140-6736(20)30183-5
Mao L, Wang M, Chen S, He Q, Chang J. Neurological manifestations of hospitalized patients with covid-19 in Wuhan, China: A retrospective case series study; 2020.
Wu Y, Xu X, Chen Z, Duan J, Hashimoto K, Yang L, et al. Nervous system involvement after infection with COVID-19 and other coronaviruses. Brain Behav Immun; 2020. Jul;87:18–22.
Chen PM, Hemmen TM. Evolving healthcare delivery in neurology during the coronavirus disease 2019 (covid-19) pandemic; 2020. 11(May):1–5.
Wang H. Potential neurological symptoms of covid-19; 2020. 1–2. DOI: 10.1177/1756286420917830
Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China 2019. N Engl J Med; 2020. 382(8):727–33. Available from:
Borges do Nascimento IJ, von Groote TC, O’Mathúna DP, Abdulazeem HM, Henderson C, Jayarajah U, et al. Clinical, laboratory and radiological characteristics and outcomes of novel coronavirus (SARS-CoV-2) infection in humans: A systematic review and series of meta-analyses. PLoS One [Internet]; 2020. Sep 17;15(9):e0239235.
Tian S, Hu N, Lou J, Chen K, Kang X, Xiang Z, et al. Characteristics of COVID-19 infection in Beijing. J Infect; 2020. Apr;80(4):401–6.
Abdel-Mannan O, Eyre M, Löbel U, Bamford A, Eltze C, Hameed B, et al. Neurologic and radiographic findings associated with covid-19 Infection in Children. JAMA Neurol [Internet]; 2020. Nov 1;77(11):1440–5. Available from: https://pubmed.ncbi.nlm.nih.gov/32609336
Trigo J, García-Azorín D, Planchuelo-Gómez Á, Martínez-Pías E, Talavera B, Hernández-Pérez I, et al. Factors associated with the presence of headache in hospitalized covid-19 patients and impact on prognosis: A retrospective cohort study. J Headache Pain; 2020. 21(1):1–10. DOI: 10.1186/s10194-020-01165-8
García-Azorín D, Sierra Á, Trigo J, Alberdi A, Blanco M, Calcerrada I, et al. Frequency and phenotype of headache in covid-19: A study of 2194 patients. Sci Rep [Internet]; 2021. 11(1):1–10.
Zhang H, Penninger JM, Li Y, Zhong N, Slutsky AS. Angiotensin ‑ converting enzyme 2 (ACE2) as a sars ‑ cov 2 receptor: Molecular mechanisms and potential therapeutic target. Intensive Care Med [Internet]. 46(4):586–90. DOI: 10.1007/s00134-020-05985-9
Varga Z, Flammer AJ, Steiger P, Haberecker M, Andermatt R, Zinkernagel AS, et al. Correspondence endothelial cell infection and endotheliitis in. Lancet [Internet]; 2019. 395(10234):1417–8.
Edvinsson L, Haanes KA, Warfvinge K. Does inflammation have a role in migraine? Nat Rev Neurol [Internet]; 2019. 15(8):483–90.
Qin C, Zhou L, Hu Z, Zhang S, Yang S, Tao Y, et al. Dysregulation of immune response in patients with coronavirus 2019 (covid-19) in Wuhan, China. Clin Infect Dis [Internet]; 2020. Jul;71(15):762–8. Available from:
Zhang H-J, Qi G-Q, Gu X, Zhang X-Y, Fang Y-F, Jiang H, et al. Lymphocyte blood levels that remain low can predict the death of patients with covid-19. Medicine (Baltimore) [Internet]; 2021 Jul;100(28):e26503. Available from: https://journals.lww.com/md-journal/Fulltext/2021/07160/Lymphocyte_blood_levels_that_remain_low_can.10.aspx
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