THE PROFILE OF COGNITIVE FUNCTION OF PATIENTS HIV/AIDS IN Dr. SAIFUL ANWAR MALANG HOSPITAL

Authors

  • Herpan Syafii Harahap Laboratorium Neurologi Fakultas Kedokteran Universitas Brawijaya, Malang
  • Sri Budhi Rianawati Laboratorium Neurologi Fakultas Kedokteran Universitas Brawijaya, Malang

Keywords:

HIV/AIDS, cognitive function, MMSE, CDT

Abstract

Background. HIV/AIDS caused cellular immunodeficiency (the depletion of CD4+). This, in turn, raised many complications, such as HIV-associated dementia (HIV-D).
Objective. To know the profile of cognitive function of patients of HIV/AIDS tretaed in Dr. Saiful Anwar Malang Hospital.
Methods. This was a descriptive study using cross-sectional design. This study was conducted to 41 patients of HIV/AIDS treated in Dr. Saiful Anwar Malang Hospital during January to February 2012 (n=41). The cognitive function was assessed by using Mini Mental State Examination (MMSE) and Clock Drawing Test (CDT) instruments.
Results. In MMSE, Number of patients showing total score 0-16 were 9 (21.95%), those showing total score 17-23 were 25 (60.98%), and those showing total score 24-30 were 7 (17.07%) . In CDT, 37 patients showed decrease of cognitive function (CDT<4), the remainder showed normal cognitive function. All of patients showing total score of both MMSE and CDT below normal limit, showed low level of CD4 (< 200 sel/µL). Patients showing normal cognitive function on CDT, also showing the same result on MMSE.
Conclusion. Most of patients in this study showed the decrease of cognitive function.

References

WHO. 2011. Global HIV/AIDS Response: Epidemic update and health sector progress toward Universal Access. Progress Report 2011.

Roos KL, et al. 2005. Principles of Neurologic Infectious Disease. USA: The McGraw-Hill Companies, Inc. p113-30

Sereia AL, et al. Mini mental state examination and evaluation of factors associated with cognitive decline in HIV/AIDS-infected people. Acta Scientarium 2012; 34(2): 193-8

Wilkie FL, et al. Mild Cognitive Impairment and Risk of Mortality in HIV-1 Infection. J Neuropsychiatry and Clin Neurosci 1998; 10:125–32

Schouten J, et al. HIV-1 infection and cognitive impairment in the cART-era: a review. AIDS 2011;25:1-16

Rosenberg PB, Johnston D, Lyketsos CG. A Clinical Approach to Mild Cognitive Impairment. Am J Psychiatry 2006; 163(11): 1884-9

Mittal C, Gorthi CSP, Rohatgi MGS. Early Cognitive Impairment: Role of Clock Drawing Test. MJAFI 2010; 66 : 25-8

Lawler K, et al. Neurocognitive impairment among HIV-positive individuals in Botswana: a pilot study. J International AIDS Society 2010;13:15

Robertson KR, et al. The prevalence and incidence of neurocognitive impairment in the HAART era. AIDS 2007, 21:1915–21

Sacktor N, et al. HIV-associated cognitive impairment before and after the advent of combination therapy. J NeuroVirology 2002; 8: 136-42

Ellis RJ. Evidence-Based Treatment for HIVAssociated Dementia and Cognitive Impairment: Why So Little?. PLOS 2007;2(3):e15

Shojania S, et al. High yield expression and purification of HIV-1 Tat1−72 for structural studies. Journal of Virological Methods 2009;8: 1-7

Block ML, Zecca L, Hong JS. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. NEUROSCIENCE 2007;8:57-65

Pokdi Fungsi Luhur. 2010. Panduan Pemeriksaan Neurologi dan Neurobehavior. Jakarta: PERDOSSI.

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Published

2015-01-01

How to Cite

Harahap, H. S., & Rianawati, S. B. (2015). THE PROFILE OF COGNITIVE FUNCTION OF PATIENTS HIV/AIDS IN Dr. SAIFUL ANWAR MALANG HOSPITAL. MNJ (Malang Neurology Journal), 1(1), 1–6. Retrieved from https://mnj.ub.ac.id/index.php/mnj/article/view/6

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Section

Research Article