KEARNS-SAYRE SYNDROME MIGHT BE MIXED UP WITH CPEO PLUS
Keywords:
Mitochondrial, Kearns-Sayre syndrome, mtDNA, seizures, stroke-like episodes, phenotype, genotype, multisystem disease, lactic acidosisAbstract
In a recent article, Al Ghamdi presented a 40yo parturient with Kearns-Sayre syndrome (KSS) who had received an implantable cardioverter defibrillator (ICD) because of an AVblock II (Mobitz 2 (2:1)) 11y earlier and underwent caesarean delivery for preeclampsia in local anesthesia with bupivacaine and fentanyl.(1) We have the following comments and concerns.
References
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Seneca S, Verhelst H, De Meirleir L, Meire F, Ceuterick-De Groote C, Lissens W, Van Coster R. A new mitochondrial point mutation in the transfer RNA (Leu) gene in a patient with a clinical phenotype resembling Kearns-Sayre syndrome. Arch Neurol; 2001.58:1113-8. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/11448301
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