CORRELATION OF C-REACTIVE PROTEIN LEVELS WITH CLINICAL OUTCOME INTRACEREBRAL HEMORRHAGE STROKE PATIENTS
Keywords:
Intracerebral Haemorrhage stroke, C-Reactive Protein, Barthel IndexAbstract
Background. Increased levels of markers of inflammatory factors after hemorrhage stroke was able to predict poor clinical outcome. Until now, the role of C Reactive Protein (CRP) in the local inflammatory response and clinical determinants output remains unclear.
Objective. To investigate the correlation of CRP level with poor clinical outcome as measured by Barthel Index.
Methods. This study was an observasional cohort porspective study performed on haemorrhage stroke patients in Saiful Anwar General Hospital in Februari 2014 until April 2014.
Results. There was significant correlation (p=0,01, r=0,613) between CRP levels to poor clinical outcome measured by Barthel Index.
Conclusion. C Reactive Protein levels could predict poor clinical outcome as measured by Barthel Index in intracerebral hemorrhage patients.
References
Qureshi IA, Tuhrim S, Broderick JP, Batjer H, Hondo H, Hanley FP. Spontaneus intracerebral hemorrhage. The New England Journal of Medicine. 2001; 19: 1450-1460.
Wang J, Tsirka SE. Contribution of extracellular proteolysis and microglia to intracerebral hemorrhage. Neu. Crit. Care. 2005; 3: 77-85.
Godoy DA, Pinero G, Di Napoli M. Predicting Mortality in Spontaneou Intracerebral Hemorrhage: Can Modification to Original Score Improve the Prediction?. Stroke. 2006; 37:1038-1044.
Di Napoli M, Elkind SVM, Godoy AD. Role of Creactive protein in Cerebrovascular disease: a critical review. Expert Rev.Cardivasc.Ther. 2011; 9(12): 1565-1584.
Huang FP. Brain edema After experimental Intracerebral Hemorrhage: role of Hemoglobin Degradation Product. J Neurosurg. 2002; 96:287-293.
Inaji M et al. Chronological changes of perihematoma edema of human intracerebral hematom Acta Neurochir Suppl. 2003; 86:44548.
Kenneth R et al. Heme and Iron Metabolism: Role in Cerebral Hemorrhage Review Article Journal of Cerebral Blood Flow & Metabolism. 2003; 23:629-652.
Wang TJ, Nam BH, Wilson PW et al. Association of C-reactive protein with carotid atherosclerosis in men and women. The Framingham Heart Study Artherioscler. Thromb. Vasc.Biol. 2002; 22(10):1662-1667.
Masada T. Overexpression of Intracerebral Hemorrhage and Thrombin. Acta Neurochir. 2003; 86:463-467.
Di Napoli M, Godoy DA, Campi V et al. Creactive protein in intracerebral hemorrhage: time, course, tissue location, and prognosis. Neurology. 2012; 79:690-699.
Uyttenboogart M. Optimizing Cutoff Scores for the Bathel Index and the Modified Rankin Scale for Defining Outcome in Acute Stroke Trials. Stroke. 2005; 36:1984-1987.
Flaherthy LM, Woo D, Haverbusch M et al. Potential Applicability of Recombinant Factor VIIa for Intracerebral Hemorrhage. Stroke. 2005;36:2660-2664
